研究成果

  • 論文タイトル :Local brain environment changes associated with epileptogenesis.
    著者:Ikoma Y, Sasaki D, Matsui K.
    雑誌情報 :Brain. DOI: https://doi.org/10.1093/brain/awac355.

  • 論文タイトル :Synaptic pruning through glial synapse engulfment during motor learning.
    著者:Morizawa YM, Matsumoto M, Nakashima Y, Endo N, Aida T, Ishikane H, Beppu K, Moritoh S, Inada H, Osumi N, Shigetomi E, Koizumi S, Yang G, Hirai H, Tanaka K, Tanaka KF, Ohno N, Fukazawa Y, Matsui K.
    雑誌情報 :Nature Neuroscience. 2022 25;1458-1469. DOI:https://doi.org/10.1038/s41593-022-01184-5.

  • 論文タイトル :Hippocampus-related cognitive disorders develop in the absence of epilepsy and ataxia in the heterozygous Cacna1a mutant mice tottering.
    著者:Nakao A, Hayashida K, Ogura H, Mori Y, Imoto K.
    雑誌情報 :Channels (Austin).2022 Dec;16(1):113-126. doi: 10.1080/19336950.2022.2072449.

  • 論文タイトル :Long-lasting beneficial effects of maternal intake of sulforaphane glucosinolate on gut microbiota in adult offspring.
    著者:Wei Y, Chang L, Liu G, Wang X, Yang Y, Hashimoto K.
    雑誌情報 : J. Nutr. Biochem. 2022 November; 109: 109098. doi: 10.1016/j.jnutbio.2022.109098.

  • 論文タイトル :Effects of spleen nerve degeneration on depression-like phenotype, systemic inflammation, and abnormal composition of gut microbiota in mice after administration of lipopolysaccharide: A role of brain-spleen axis.
    著者:Ma L, Zhang J, Fujita Y, Shinno-Hashimoto H, Shan J, Wan X, Qu Y, Chang L, Wang X, Hashimoto K.
    雑誌情報 : J. Affect. Disord.2022 November 15; 317: 156-165. doi: 10.1016/j.jad.2022.08.087.

  • 論文タイトル :A role of miR-149 in the prefrontal cortex for prophylactic actions of (R)-ketamine in inflammation model.
    著者:Ma L, Wang L, Chang L, Shan J, Qu Y, Wang X, Fujita Y, Hashimoto K.
    雑誌情報 :Neuropharmacology.2022 Nov 15; 219: 109250. doi: 10.1016/j.neuropharm.2022.109250.

  • 論文タイトル :Gut-microbiota-brain axis in the vulnerbility to psychosis in adulthood after repeated cannabis exposure during adolescence.
    著者:Wan X, Eguchi A, Qu Y, Yang Y, Chang L, Shan J, Mori C, Hashimoto K.
    雑誌情報 :Eur. Arch. Psychiatry Clin. Neurosci.2022 October; 272(7): 1297-1309. doi: 10.1007/s00406-022-01437-1.

  • 論文タイトル :Chondroitin sulfate proteoglycan is a potential target of memantine to improve cognitive function via the promotion of adult neurogenesis.
    著者:Maeda S, Yamada J, Iinuma KM, Nadanaka S, Kitagawa H, Jinno S.
    雑誌情報 :Br J Pharmacol.2022 Oct;179(20):4857-4877. doi: 10.1111/bph.15920.

  • 論文タイトル :Alleviation of cognitive deficits via upregulation of chondroitin sulfate biosynthesis by lignan sesamin in a mouse model of neuroinflammation.
    著者:Yamada J, Maeda S, Soya M, Nishida H, Iinuma KM, Jinno S.
    雑誌情報 :J Nutr Biochem.2022 Oct;108:109093. doi: 10.1016/j.jnutbio.2022.109093.

  • 論文タイトル :Contextual fear conditioning regulates synapse-related gene transcription in mouse microglia.
    著者:Yu Z, Sakai M, Fukushima H, Ono C, Kikuchi Y, Koyama R, Matsui K, Furuyashiki T, Kida S, Tomita H.
    雑誌情報 :Brain Res Bull.2022 Oct 15;189:57-68.doi: 10.1016/j.brainresbull.2022.08.017.

  • 論文タイトル :Depression-like behaviors in mouse model of Sjögren’s syndrome: A role of gut–microbiota–brain axis.
    著者:Pu Y, He Y, Zhao X, Zhang Q, Wen J, Hashimoto K, Liu Y.
    雑誌情報 :Pharmacol. Biochem. Behav.2022 September; 219: 173448.doi: 10.1016/j.pbb.2022.173448.

  • 論文タイトル :A role of gut–microbiota–brain axis via subdiaphragmatic vagus nerve in depression-like phenotypes in Chrna7 gene knock-out mice.
    著者:Yang Y, Eguchi A, Wan X, Chang L, Wang X, Qu Y, Mori C, Hashimoto K.
    雑誌情報 :Prog. Neuropsychopharmacol. Biol. Psychiatry.2022 Sep 30;120:110652. doi: 10.1016/j.pnpbp.2022.110652.

  • 論文タイトル :A feedback loop between lamellipodial extension and HGF-ERK signaling specifies leader cells during collective cell migration.
    著者:Hino N, Matsuda K, Jikko Y, Maryu G, Sakai K, Imamura R, Tsukiji S, Aoki K, Terai K, Hirashima T, Trepat X, Matsuda M.
    雑誌情報 :Dev Cell.2022/9/26; 57:1-15. doi: 10.1016/j.devcel.2022.09.003.

  • 論文タイトル :Ischemic Tolerance Induced by Glial Cells.
    著者:Koizumi S, Hirayama Y.
    雑誌情報 :Neurochem Res. 2022 Sep;47(9):2522-2528. doi: 10.1007/s11064-022-03704-y.

  • 論文タイトル :Strategies for Manipulating Microglia to Determine Their Role in the Healthy and Diseased Brain.
    著者:Parajuli B, Koizumi S.
    雑誌情報 :Neurochem Res. 2022 Sep 9;1-11. doi: 10.1007/s11064-022-03742-6.

  • 論文タイトル :The role of astrocytes in behaviors related to emotion and motivation.
    著者:Shigetomi E, Koizumi S.
    雑誌情報 :Neurosci Res.2022 Sep 28;S0168-0102(22)00260-7. doi: 10.1016/j.neures.2022.09.015.

  • 論文タイトル :Separate optogenetic manipulation of Nerve/glial antigen 2 (NG2) glia and mural cells using the NG2 promoter.
    著者:Oishi M, Passlick S, Yamazaki Y, Unekawa M, Adachi R, Yamada M, Imayoshi I, Abe Y, Steinhäuser C, Tanaka KF.
    雑誌情報 :Glia.2022 Sep 27. doi: 10.1002/glia.24273. Online ahead of print. PMID: 36165697

  • 論文タイトル :The microglia-blood vessel interactions in the developing brain.
    著者:Hattori Y.
    雑誌情報 :Neurosci Res.2022 Sep 24.DOI: https://doi.org/10.1016/j.neures.2022.09.006.

  • 論文タイトル :Microglia and GABA: Diverse functions of microglia beyond GABA-receiving cells.
    著者:Andoh M, Koyama R.
    雑誌情報 :ANeurosci Res.2022 Sep 21:S0168-0102(22)00253-X. doi: 10.1016/j.neures.2022.09.008.

  • 論文タイトル :Estimating infection-related human mobility networks based on time series data of COVID-19 infection in Japan.
    著者:Yamada, Tetsuya; Shi, Shoi.
    雑誌情報 :Applied Sciences.2022 Sep 15;12(18):9236.doi: 10.3390/app12189236.

  • 論文タイトル :Mental health during the COVID-19 pandemic, impact of childhood trauma in psychiatric disorders, and predictable biomarkers for bipolar disorder.
    著者:Hashimoto K.
    雑誌情報 :Eur. Arch. Psychiatry Clin. Neurosci.2022 August; 272(5): 753-755. doi: 10.1007/s00406-022-01445-1.

  • 論文タイトル :In Vivo Wide-Field and Two-Photon Calcium Imaging from a Mouse using a Large Cranial Window.
    著者:Manita S, Shigetomi E, Bito H, Koizumi S Kitamura K.
    雑誌情報 :J Vis Exp.2022 Aug 4;(186). doi: 10.3791/64224.

  • 論文タイトル :Special issue on “Brain-body communication in health and diseases”.
    著者:Hashimoto K, Yang C.
    雑誌情報 :Brain Res. Bull.2022 August; 186: 47-49. doi: 10.1016/j.brainresbull.2022.05.014.

  • 論文タイトル :(R)-ketamine as prophylactic and therapeutic drug for neurological disorders: beyond depression.
    著者:Wang X, Yang JJ, Hashimoto K.
    雑誌情報 :Neurosci. Biobehav. Rev.2022 August, 139: 104762 doi: /10.1016/j.neubiorev.2022.104762.

  • 論文タイトル :Vital but vulnerable: Human TRPV6 is a trade-off of powerful Ca2+ uptake and susceptibility to epithelial barrier dysfunction.
    著者:Mori Y, Omori M, Nakao A.
    雑誌情報 :Cell Calcium.2022 Sep 13;107:102652. doi: 10.1016/j.ceca.2022.102652.

  • 論文タイトル :Multiple types of navigational information are independently encoded in the population activities of the dentate gyrus neurons.
    著者:Murano T, Nakajima R, Nakao A, Hirata N, Amemori S, Murakami A, Kamitani Y, Yamamoto J, Miyakawa T.
    雑誌情報 :Proc Natl Acad Sci USA. 2022 Aug 9;119(32):e2106830119. doi: 10.1073/pnas.2106830119.

  • 論文タイトル :Identification of hyper-ramified microglia in the CA1 region of the mouse hippocampus potentially associated with stress resilience.
    著者:Fujikawa R, Jinno S.
    雑誌情報 :Eur J Neurosci. 2022 Aug 26. doi: 10.1111/ejn.15812.

  • 論文タイトル :Effects of (R)-ketamine on reduced bone mineral density in ovariectomized mice: a role of gut microbiota.
    著者:Wan X, Eguchi A, Fujita Y, Ma L, Wang X, Yang Y, Qu Y, Chang L, Zhang J, Mori C, Hashimoto K.
    雑誌情報 :Neuropharmacology.2022 August 1; 213: 109139. doi: 10.1016/j.neuropharm.2022.109139.

  • 論文タイトル :Simultaneous Imaging of Microglial Dynamics and Neuronal Activity in Awake Mice.
    著者:Maruoka H, Kamei R, Mizutani M, Liu Q, Okabe S.
    雑誌情報 :J. Vis. Exp.2022 Aug 23;(186). doi: 10.3791/64111.

  • 論文タイトル :PCR-based profiling of transcription factor activity in vivo by a virus-based reporter battery.
    著者:Hitomi Abe, Kentaro Abe.
    雑誌情報 :STAR Protocols.2022 Aug 18;3(3):101633. doi: 10.1016/j.xpro.2022.101633.

  • 論文タイトル :Effects of (R)-ketamine on reduced bone mineral density in ovariectomized mice: a role of gut microbiota.
    著者:Wan X, Eguchi A, Fujita Y, Ma L, Wang X, Yang Y, Qu Y, Chang L, Zhang J, Mori C, Hashimoto K.
    雑誌情報 :Neuropharmacology.2022 August 1; 213: 109139. doi: 10.1016/j.neuropharm.2022.109139.

  • 論文タイトル :The role of hippocampal KCNQ2 in antidepressant effects of ketamine.
    著者:Ma L, Hashimoto K.
    雑誌情報 :Neuron.2022 July 20; 110(14): 2201-2203. doi: 10.1016/j.neuron.2022.05.027.

  • 論文タイトル :Controlled activation of cortical astrocytes modulates neuropathic pain-like behaviour.
    著者:Takeda I, Yoshihara K, Cheung DL, Kobayashi T, Agetsuma M, Tsuda M, Eto K, Koizumi S, Wake H, Moorhouse AJ, Nabekura J.
    雑誌情報 :Nat Commun.2022 Jul 14;13(1):4100. doi: 10.1038/s41467-022-31773-8.

  • 論文タイトル :Replacement of Mouse Microglia With Human Induced Pluripotent Stem Cell (hiPSC)-Derived Microglia in Mouse Organotypic Slice Cultures.
    著者:Ogaki A, Ikegaya Y, Koyama R.
    雑誌情報 :Front Cell Neurosci.2022 Jul 13;16:918442. doi: 10.3389/fncel.2022.918442. eCollection 2022.

  • 論文タイトル :The gut-liver axis in sepsis: interaction mechanisms and therapeutic potential.
    著者:Zhang X, Hashimoto K, Yuan S, Zhang J.
    雑誌情報 :Crit. Care.2022 July 13; 26(1): 213. doi: 10.1186/s13054-022-04090-1.

  • 論文タイトル :Gut–microbiota–brain axis by bile acids in depression.
    著者:Hashimoto K.
    雑誌情報 :Psychiatry Clin. Neurosci.2022 July; 76(7): 281. doi: 10.1111/pcn.13370.

  • 論文タイトル :In vivo Chronic Two-Photon Imaging of Microglia in the Mouse Hippocampus.
    著者:Kamei R, Urata S, Maruoka H, Okabe S.
    雑誌情報 :J. Vis. Exp. 2022 Jul 6;(185). doi: 10.3791/64104.

  • 論文タイトル :Fecal microbiota transplantation from patients with rheumatoid arthritis causes depression-like behaviors in mice through abnormal T cells activation.
    著者:Pu Y, Zhang Q, Tang Z, Lu C, Wu L, Zhong Y, Chen Y, Hashimoto K, Luo Y, Liu Y.
    雑誌情報 :Transl. Psychiatry. 2022 June 01; 12: 223. doi: 10.1038/s41398-022-01993-z.

  • 論文タイトル :Single transcription factor efficiently leads human induced pluripotent stem cells to functional microglia.
    著者:Sonn I, Honda-Ozaki F, Yoshimatsu S, Morimoto S, Watanabe H, Okano H.
    雑誌情報 :Inflamm Regen. 2022 Jul 1;42(1):20. doi: 10.1186/s41232-022-00201-1.

  • 論文タイトル :Phagocytic astrocytes: emerging from the shadows of microglia.
    著者:Konishi H, Koizumi S and Kiyama H.
    雑誌情報 :GLIA. 2022 Jun;70(6):1009-1026. doi: 10.1002/glia.24145.

  • 論文タイトル :P2X7 receptors in astrocytes; as a switch for ischemic tolerance.
    著者:Hirayama Y, Anzai N, Kinouchi, H and Koizumi S.
    雑誌情報 :Molecules. 2022 Jun 7;27(12):3655. doi: 10.3390/molecules27123655.

  • 論文タイトル :Brain–spleen axis in health and diseases: A review and future perspective.
    著者:Wei Y, Wang T, Liao L, Fan X, Chang L, Hashimoto K.
    雑誌情報 :Brain Res. Bull. 2022 May; 182: 130-140. doi:10.1016/j.brainresbull.2022.02.008.

  • 論文タイトル :Brain–gut–microbiota axis in depression: A historical overview and future directions.
    著者:Chang L, Wei Y, Hashimoto K.
    雑誌情報 :Brain Res. Bull. 2022 May; 182: 44-56. doi: 10.1016/j.brainresbull.2022.02.004.

  • 論文タイトル :Transplantation of Human Induced Pluripotent Stem Cell-derived Microglia in Immunocompetent Mice Brain via Non-invasive Transnasal Route.
    著者:Parajuli B, Shonozaki Y, Shigetomi E and Koizumi S.
    雑誌情報 :J Vis Exp. 2022 May 31;(183). doi: 10.3791/63574.

  • 論文タイトル :Effects of Subdiaphragmatic Vagotomy in the MPTP-induced Neurotoxicity in the Striatum and Colon of Mice.
    著者:Shan J, Qu Y, Zhang J, Ma L, Hashimoto K.
    雑誌情報 :Clin. Psychopharmacol. Neurosci. 2022 May 31; 20(2): 389-393. doi: 10.9758/cpn.2022.20.2.389.

  • 論文タイトル :Actin-binding protein filamin-A drives tau aggregation and contributes to progressive supranuclear palsy pathology.
    著者:Tsujikawa K, Hamanaka K, Riku Y, Hattori Y, Hara N, Iguchi Y, Ishigaki S, Hashizume A, Miyatake S, Mitsuhashi S, Miyazaki Y, Kataoka M, Jiayi L, Yasui K, Kuru S, Koike H, Kobayashi K, Sahara N, Ozaki N, Yoshida M, Kakita A, Saito Y, Iwasaki Y, Miyashita A, Iwatsubo T, Japanese Alzheimer’s Disease Neuroimaging Initiative, J-ADNI, Ikeuchi T, Japanese Longitudinal Biomarker Study in PSP and CBD (JALPAC) Consortium, Miyata T, Sobue G, Matsumoto N, Sahashi K, Katsuno M.
    雑誌情報 :Sci Adv.2022 May 25; 8(21).DOI: https://doi.org/10.1126/sciadv.abm5029

  • 論文タイトル :A Novel Device of Reaching, Grasping, and Retrieving Task for Head-Fixed Mice.
    著者:Manita S, Ikezoe K Kitamura K.
    雑誌情報 :Frontiers in Neural Circuits.2022 May 12; 16 doi:ARTN 842748 10.3389/fncir.2022.842748.

  • 論文タイトル :(R)-ketamine ameliorates demyelination and facilitates remyelination in cuprizone-treated mice: A role of gut–microbiota–brain axis.
    著者:Wang X, Chang L, Wan X, Tan Y, Qu Y, Shan J, Yang Y, Ma L, Hashimoto K.
    雑誌情報 :Neurobiol. Dis. 2022 April; 165: 105635. doi:10.1016/j.nbd.2022.105635.

  • 論文タイトル :Soluble epoxide hydrolase as a therapeutic target for neuropsychiatric disorders.
    著者:Shan J, Hashimoto K.
    雑誌情報 :Int. J. Mol. Sci. 2022 April 29; 23: 4951. doi: 10.3390/ijms23094951.

  • 論文タイトル :Ketamine: anesthetic, psychotomimetic, antidepressant, or anthelmintic?
    著者:Hashimoto K.
    雑誌情報 :Mol Psychiatry.2022 Apr 27. doi: 10.1038/s41380-022-01587-7.

  • 論文タイトル :A spinal microglia population involved in remitting and relapsing neuropathic pain.
    著者:Kohno K, Shirasaka R, Yoshihara K, Mikuriya S, Tanaka K, Takanami K, Inoue K, Sakamoto H, Ohkawa Y, Masuda T, Tsuda M.
    雑誌情報 :Science.2022 Apr; 376(6588):86-90. doi: 10.1126/science.abf6805.

  • 論文タイトル :Transient astrocytic mGluR5 expression drives synaptic plasticity and subsequent chronic pain in mice.
    著者:Danjo Y, Shigetomi E, Hirayama YJ, Kobayashi K, Ishikawa T, Fukazawa Y, Shibata K, Takanashi K, Parajuli B, Shinozaki Y, Kim SK, Nabekura J and *Koizumi S.
    雑誌情報 :J Exp Med.2022 Apr 4;219(4):e20210989. doi: 10.1084/jem.20210989.

  • 論文タイトル :The 103,200-arm acceleration dataset in the UK Biobank revealed a landscape of human sleep phenotypes.
    著者:Katori, Machiko; Shi, Shoi; Ode, Koji L; Tomita, Yasuhiro; Ueda, Hiroki R.
    雑誌情報 :Proceedings of the National Academy of Sciences of the United States of America.2022 Mar 22;119(12):e2116729119.doi:10.1073/pnas.2116729119.

  • 論文タイトル :A design principle of spindle oscillations in mammalian sleep.
    著者:Yamada, Tetsuya; Shi, Shoi; Ueda, Hiroki R.
    雑誌情報 :iScience.2022 Mar 18;103873.doi: 10.1016/j.isci.2022.103873.

  • 論文タイトル :Phytoestrogen genistein modulates neuron-microglia signaling in a mouse model of chronic social defeat stress.
    著者:Fujikawa R, Yamada J, Iinuma KM, Jinno S.
    雑誌情報 :Neuropharmacology. 2022 Mar 15;206:108941. doi: 10.1016/j.neuropharm.2021.108941.

  • 論文タイトル :C-type Natriuretic Peptide-induced PKA Activation Promotes Endochondral Bone Formation in Hypertrophic Chondrocytes.
    著者:Hirota K, Hirashima T, Horikawa K, Yasoda A, Matsuda M.
    雑誌情報 :Endocrinology.2022/3/1; 163(3):1-12. doi: 10.1210/endocr/bqac005.

  • 論文タイトル :Optogenetic stimulus-triggered acquisition of seizure resistance.
    著者:Shimoda Y, Beppu K, Ikoma Y, Morizawa YM, Zuguchi S, Hino U, Yano R, Sugiura Y, Moritoh S, Fukazawa Y, Suematsu M, Mushiake H, Nakasato N, Iwasaki M, Tanaka KF, Tominaga T, Matsui K.
    雑誌情報 :Neurobiol Dis. 2022 Feb;163:105602. doi: 10.1016/j.nbd.2021.105602. Epub 2021 Dec 24. PMID: 34954320.

  • 論文タイトル :Imaging neural circuit pathology of autism spectrum disorders: autism-associated genes, animal models and the application of in vivo two-photon imaging.
    著者:Terashima H, Minatohara K, Maruoka H, Okabe S.
    雑誌情報 :Microscopy (Oxf). 2022 Feb 18;71(Supplement_1):i81-i99. doi: 10.1093/jmicro/dfab039.

  • 論文タイトル :A jerk-based algorithm ACCEL for the accurate classification of sleep–wake states from arm acceleration.
    著者:Ode, Koji L; Shi, Shoi; Katori, Machiko; Mitsui, Kentaro; Takanashi, Shin; Oguchi, Ryo; Aoki, Daisuke; Ueda, Hiroki R
    雑誌情報 :iScience. 2022 Feb 18;103727.doi: 10.1016/j.isci.2021.103727.

  • 論文タイトル :Protocol for viral vector-mediated measurement of transcription factor activity of mouse brain.
    著者:Yamamoto H, Abe K.
    雑誌情報 :iScience. Neurosci. 2022 Feb 14;25(3):103927. doi: 10.1016/j.isci.2022.103927.

  • 論文タイトル :Glial Purinergic Signals and Psychiatric Disorders.
    著者:Koizumi S.
    雑誌情報 :Front. Cell. Neurosci. 2022 Jan 5;15:822614. doi: 10.3389/fncel.2021.822614.

  • 論文タイトル :The Mlc1 promotor directs Müller cell-specific gene expression in the retina.
    著者:Danjo Y, Shinozaki Y, Natsubori A, Kubota Y, Kashiwagi K, Tanaka KF and Koizumi S.
    雑誌情報 :TVST. 2022 Jan 3;11(1):25. doi: 10.1167/tvst.11.1.25.

  • 論文タイトル :Stress-induced antinociception to noxious heat requires α1A-adrenaline receptors of spinal inhibitory neurons in mice.
    著者:Uchiyama S, Yoshihara K, Kawanabe R, Hatada I, Koga K, Tsuda M.
    雑誌情報 :Mol Brain. 2022 Jan 3; 15(1):6. doi: 10.1186/s13041-021-00895-3

  • 論文タイトル :Embryonic pericytes promote microglial homeostasis and their effects on neural progenitors in the developing cortex.
    著者:Hattori Y, Itoh H, Tsugawa Y, Nishida Y, Kurata K, Uemura A, Miyata T.
    雑誌情報 :J Neurosci. 2022 Jan 19; 42(3), 362–376.DOI: https://doi.org/10.1523/JNEUROSCI.1201-21.2021

  • 論文タイトル :Nerve-macrophage interactions in cardiovascular disease.
    著者:Fujiu K, Manabe I.
    雑誌情報 :Int Immunol.2022 Jan;34(2):81-95. doi: 10.1093/intimm/dxab036.

  • 論文タイトル :Amyloid β (Aβ) ELISA of Human iPSC-Derived Neuronal Cultures.
    著者:Watanabe H, Murakami R, Okano H.
    雑誌情報 :Methods Mol Biol. 2022;2549:209-217. doi: 10.1007/7651_2021_407.

  • 論文タイトル :Abnormal Ca2+ Signals in Reactive Astrocytes as a Common Cause of Brain Diseases.
    著者:Koizumi S, Shigetomi E, Sano F, Saito K, Kim SK, Nabekura J.
    雑誌情報 :Int.J.Mol. Sci. 2021 Des 23;(1):149. doi: 10.3390/ijms23010149.

  • 論文タイトル :A dual promoter system to monitor IFN-γ signaling in vivo at single-cell resolution.
    著者:Tanaka, T., Konishi, Y., Ichise, H., Tsukiji, S., Matsuda, M., and Terai, K.
    雑誌情報 :Cell Struct. Funct.2021/12/22; 46(2):103-111. doi: 10.1247/csf.21052.

  • 論文タイトル :Spinal glial cells in itch modulation.
    著者:Shiratori-Hayashi M, Tsuda M.
    雑誌情報 :Pharmacol Res Perspect. 2021 Dec; 9(6):e00754. doi: 10.1002/prp2.754.

  • 論文タイトル :Advanced Technologies for Local Neural Circuits in the Cerebral Cortex.
    著者:Endo M, Maruoka H, Okabe S.
    雑誌情報 :Front. Neuroanat.2021 Nov 3;15:757499. doi: 10.3389/fnana.2021.757499.

  • 論文タイトル :Holographic microscope and its biological application.
    著者:Quan X, Kato D, Daria V, Matoba O, Wake H.
    雑誌情報 :Neurosci Res.2021 Nov 2;S0168-0102(21)00220-0. doi: 10.1016/j.neures.2021.10.012.

  • 論文タイトル :Redundant roles of EGFR ligands in the ERK activation waves during collective cell migration.
    著者:Lin, S., Hirayama, D., Maryu, G., Matsuda, K., Hino, N., Deguchi, E., Aoki, K., Iwamoto, R., Terai, K., and Matsuda, M.
    雑誌情報 :Life Sci Alliance.2021/10/21; 5(1):e202101206. doi: 10.26508/lsa.202101206.

  • 論文タイトル :Activation of Astrocytes in the Persistence of Post-hypoxic Respiratory Augmentation.
    著者:Fukushi I, Takeda K, Pokorski M, Kono Y, Yoshizawa M, Hasebe Y, Nakao A, Mori Y, Onimaru H, Okada Y.
    雑誌情報 :Front Physiol.2021 Oct 8;12:757731. doi: 10.3389/fphys.2021.757731.

  • 論文タイトル :The behavior and functions of embryonic microglia.
    著者:Hattori Y.
    雑誌情報 :Anat Sci Int.2021 Sep 19; 97, 1-14. DOI: https://doi.org/10.1007/s12565-021-00631-w.

  • 論文タイトル :Signal Transducer and Activator of Transcription 3 Activation in Hippocampal Neural Stem Cells and Cognitive Deficits in Mice Following Short-term Cuprizone Exposure.
    著者:Ohgomori T, Jinno S.
    雑誌情報 :Neuroscience.2021 Sep 15;472:90-102. doi: 10.1016/j.neuroscience.2021.07.031.

  • 論文タイトル :Two-photon AMPK and ATP imaging reveals the bias between rods and cones in glycolysis utility.
    著者:He J, Yamamoto M, Sumiyama K, Konagaya Y, Terai K, Matsuda M, Sato S.
    雑誌情報 :FASEB J.20219/1; 35(9):e21880. doi: 10.1096/fj.202101121R.

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    著者:Ohgomori T, Iinuma K, Yamada J, Jinno S.
    雑誌情報 :Eur J Neurosci.2021 Aug;54(3):4740-4754. doi: 10.1111/ejn.15330.

  • 論文タイトル :Oligodendrocytic Na+-K+-Cl- co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain.
    著者:Yamazaki Y, Abe Y, Fujii S, Tanaka KF.
    雑誌情報 :Nat Commun. 2021 Aug 26;12(1):5146. doi: 10.1038/s41467-021-25488-5. PMID: 34446732

  • 論文タイトル :Optical manipulation of local cerebral blood flow in the deep brain of freely moving mice.
    著者:Abe Y, Kwon S, Oishi M, Unekawa M, Takata N, Seki F, Koyama R, Abe M, Sakimura K, Masamoto K, Tomita Y, Okano H, Mushiake H, Tanaka KF.
    雑誌情報 :Cell Rep.2021 Jul 27;36(4):109427. doi: 10.1016/j.celrep.2021.109427. PMID: 34320360

  • 論文タイトル :Dietary supplementation with eicosapentaenoic acid inhibits plasma cell differentiation and attenuates lupus autoimmunity.
    著者:Kobayashi A, Ito A, Shirakawa I, Tamura A, Tomono S, Shindou H, Hedde PN, Tanaka M, Tsuboi N, Ishimoto T, Akashi-Takamura S, Maruyama S, Suganami T.
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    著者:Kato D, Wake H.
    雑誌情報 :Front Immunol.2021 Jun 15;12:650856. doi: 10.3389/fimmu.2021.650856. eCollection 2021.

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    著者:Kashiwagi Y, Okabe S.
    雑誌情報 :Anat. Sci. Int. 2021 Jun;96(3):343-358. doi: 10.1007/s12565-021-00603-0.

  • 論文タイトル :The physiological role of Homer2a and its novel short isoform, Homer2e, in NMDA receptor-mediated apoptosis in cerebellar granule cells.
    著者:Furuichi T, Muto Y, Sadakata T, Sato Y, Hayashi K, Shiraishi-Yamaguchi Y, Shinoda Y.
    雑誌情報 :Mol Brain. 2021 Jun 12;14(1):90. doi: 10.1186/s13041-021-00804-8.

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    雑誌情報 : STAR Protoc. 2021 Jul 7;2(3):100654. doi: 10.1016/j.xpro.2021.100654.

  • 論文タイトル :CAPS2 Deficiency Impairs the Release of the Social Peptide Oxytocin, as Well as Oxytocin-Associated Social Behavior.
    著者:Fujima S, Yamaga R, Minami H, Mizuno S, Shinoda Y, Sadakata T, Abe M, Sakimura K, Sano Y, Furuichi T.
    雑誌情報 : J Neurosci. 2021 May 19;41(20):4524-4535. doi: 10.1523/JNEUROSCI.3240-20.2021.

  • 論文タイトル :Activation of spinal dorsal horn astrocytes by noxious stimuli involves descending noradrenergic signaling.
    著者:Kawanabe R, Yoshihara K, Hatada I, Tsuda M.
    雑誌情報 :Mol Brain. 2021 May 10; 14(1):79. doi: 10.1186/s13041-021-00788-5.

  • 論文タイトル :Macrophages rely on extracellular serine to suppress aberrant cytokine production.
    著者:Kurita K, Ohta H, Shirakawa I, Tanaka M, Kitaura Y, Iwasaki Y, Matsuzaka T, Shimano H, Aoe S, Arima H, Ogawa Y, Ito A,Suganami T.
    雑誌情報 :Sci Rep. 2021 May 27;11(1):11137. doi: 10.1038/s41598-021-90086-w.

  • 論文タイトル :Differential pial and penetrating arterial responses examined by optogenetic activation of astrocytes and neurons.
    著者:Hatakeyama N, Unekawa M, Murata J, Tomita Y, Suzuki N, Nakahara J, Takuwa H, Kanno I, Matsui K, Tanaka KF, Masamoto K.
    雑誌情報 :Journal of Cerebral Blood Flow & Metabolism. 2021;41(10):2676-2689. doi:10.1177/0271678X211010355.

  • 論文タイトル :CAPS1 is involved in hippocampal synaptic plasticity and hippocampus-associated learning.
    著者:Ishii C, Shibano N, Yamazaki M, Arima T, Kato Y, Ishii Y, Shinoda Y, Fukazawa Y, Sadakata T, Sano Y, Furuichi T.
    雑誌情報 :Sci Rep. 2021 Apr 21;11(1):8656. doi: 10.1038/s41598-021-88009-w.

  • 論文タイトル :The autism-associated protein CHD8 is required for cerebellar development and motor function.
    著者:Kawamura A, Katayama Y, Kakegawa W, Ino D, Nishiyama M, Yuzaki M, Nakayama K I.
    雑誌情報 :Cell Rep. 2021 Apr 6;35(1):108932. doi: 10.1016/j.celrep.2021.108932.

  • 論文タイトル :Glial amplification of synaptic signals.
    著者:Beppu K, Kubo N, Matsui K.
    雑誌情報 :J Physiol. 2021 Apr;599(7):2085-2102. doi: 10.1113/JP280857.

  • 論文タイトル :The role of molecular diffusion within dendritic spines in synaptic function.
    著者:Obashi K, Taraska J W, Okabe S.
    雑誌情報 :J. Gen. Physiol. 2021 Apr 5;153(4):e202012814. doi: 10.1085/jgp.202012814.

  • 論文タイトル :α1A-adrenaline receptors in dorsal horn inhibitory neurons have an inhibitory role in the regulation of chloroquine-induced itch in mice.
    著者:Shiraishi Y, Koga K, Yamagata R, Hatada I, Shiratori-Hayashi M, Tsuda M.
    雑誌情報 :Mol Brain. 2021 Mar 16; 14(1):55. doi: 10.1186/s13041-021-00768-9.

  • 論文タイトル :The Ser19Stop single nucleotide polymorphism (SNP) of human PHYHIPL affects the cerebellum in mice.
    著者:Sugimoto H, Horii T, Hirota JN, Sano Y, Shinoda Y, Konno A, Hirai H, Ishizaki Y, Hirase H, Hatada I, Furuichi T, Sadakata T.
    雑誌情報 :Mol Brain. 2021 Mar 12;14(1):52. doi: 10.1186/s13041-021-00766-x.

  • 論文タイトル :Cardiac macrophages prevent sudden death during heart stress.
    著者:Sugita J, Fujiu K, Nakayama Y, Matsubara T, Matsuda J, Oshima T, Liu Y, Maru Y, Hasumi E, Kojima T, Seno H, Asano K, Ishijima A, Tomii N, Yamazaki M, Kudo F, Sakuma I, Nagai R, Manabe I, Komuro I.
    雑誌情報 :Nat Commun. 2021 Mar; 12(1):1910. doi: 10.1038/s41467-021-22178-0.

  • 論文タイトル :Exacerbation of epilepsy by astrocyte alkalization and gap junction uncoupling.
    著者:Onodera M, Meyer J, Furukawa K, Hiraoka Y, Aida T, Tanaka K, Tanaka KF, Rose CR, Matsui K.
    雑誌情報 :J Neurosci. 2021 Mar 10;41(10):2106-2118. doi: 10.1523/JNEUROSCI.2365-20.2020.

  • 論文タイトル :Absence of Thyroid Hormone Induced Delayed Dendritic Arborization in Mouse Primary Hippocampal Neurons Through Insufficient Expression of Brain-Derived Neurotrophic Factor.
    著者:Yajima H, Amano I, Ishii S, Sadakata T, Miyazaki W, Takatsuru Y, Koibuchi N.
    雑誌情報 :Front Endocrinol. 2021 Feb 23;12:629100. doi: 10.3389/fendo.2021.629100. eCollection 2021.

  • 論文タイトル :New inhibitory effects of cilnidipine on microglial P2X7 receptors and IL-1β release: an involvement in its alleviating effect on neuropathic pain.
    著者:Yamashita T, Kamikaseda S, Tanaka A, Tozaki-Saitoh H, Caaveiro JMM, Inoue K, Tsuda M.
    雑誌情報 :Cells. 2021 Feb 18; 10(2):434. doi: 10.3390/cells10020434.

  • 論文タイトル :Comparative Review of Microglia and Monocytes in CNS Phagocytosis.
    著者:Andoh M, Koyama R.
    雑誌情報 :Cells. 2021 Sep 27;10(10):2555. doi: 10.3390/cells10102555.

  • 論文タイトル :Extracellular Vesicles Taken up by Astrocytes.
    著者:Ogaki A, Ikegaya Y, Koyama R.
    雑誌情報 :Int J Mol Sci. 2021 Sep 29;22(19):10553.doi: 10.3390/ijms221910553.

  • 論文タイトル :Thermosensitive receptors in neural stem cells link stress-induced hyperthermia to impaired neurogenesis via microglial engulfment.
    著者:Hoshi Y, Shibasaki K, Gailly P, Ikegaya Y, Koyama R.
    雑誌情報 :Sci Adv. 2021 Nov 26;7(48):eabj8080. doi: 10.1126/sciadv.abj8080.

  • 論文タイトル :Adenosine A2B Receptor down-regulates Metabotropic Glutamate Receptor 5 in astrocytes during postnatal development.
    著者:Tanaka M, Shigetomi E, Parajuli B, Nagatomo H, Shinozaki Y, Hirayama Y, Saito K, Kubota Y, Danjo Y, Lee JH, Kim SK, Nabekura J, Koizumi S.
    雑誌情報 :GLIA, 2021 Nov: 69(11):2546-2558. doi: 10.1002/glia.24006.

  • 論文タイトル :Transnasal transplantation of human induced pluripotent stem cell-derived microglia to the brain of immunocompetent mice.
    著者:Parajuli B, Saito H, Shinozaki Y, Shigetomi E, Miwa H, Yoneda S, Omachi S, Asaki T, Takahashi K, Fujita M, Nakashima, K and Koizumi S.
    雑誌情報 :GLIA, 2021 Oct; 69(10):2332-2348. doi: 10.1002/glia.23985.

  • 論文タイトル : Mechanisms underlying sensitization of P2X7 receptors in astrocytes for induction of ischemic tolerance.
    著者:Hirayama Y, Anzai N, Koizumi S.
    雑誌情報 :GLIA, 2021 Sep; 69(9):2100-2110. DOI: 10.1002/glia.23998.

  • 論文タイトル : Loss of P2Y1 receptor triggers glaucoma-like pathology.
    著者:Hamada K, Shinozaki Y, Namekata K, Matsumoto M, Ohno N, Segawa T, Kashiwagi K, Harada T and Koizumi S.
    雑誌情報 :Br J Pharmacol, 2021 Jul 26; in press. doi: 10.1111/bph.15637.

  • 論文タイトル : Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus.
    著者:Sano F, Shigetomi E, Shinozaki Y, Tsuzukiyama H, Saito K, Mikoshiba K, Horiuchi H, Cheung DL, Nabekura J, Sugita K, Aihara M, *Koizumi S.
    雑誌情報 :JCI Insight, 2021 May10; 6(9): e135391. doi: 10.1172/jci.insight.135391.

  • 論文タイトル : The behavior and functions of embryonic microglia.
    著者:Hattori Y.
    雑誌情報 :Anat Sci Int. 2021 Sep 19; Online ahead of print. doi: 10/1007/s12565-021-00631-w

  • 論文タイトル : Specific and behaviorally consequential astrocyte Gq-GPCR signaling attenuation in vivo with ibARK.
    著者:Nagai J, Bellafard A, Qu Z, Yu X, Ollivier M, Gangwani MR, Diaz-Castro B, Coppola G, Schumacher SM, Golshani P, Gradinaru V, Khakh BS.
    雑誌情報 :Neuron. 2021 Jun 109(14):2256-2274. doi: 10.1016/j.neuron.2021.05.023

  • 論文タイトル : Optical manipulation of local cerebral blood flow in the deep brain of freely moving mice.
    著者:Abe Y, Kwon S, Oishi M, Unekawa M, Takata N, Seki F, Koyama R, Abe M, Sakimura K, Masamoto K, Tomita Y, Okano H, Mushiake H, Tanaka KF.
    雑誌情報 : Cell Rep. 2021 Jul 27;36(4):109427. doi: 10.1016/j.celrep.2021.109427

  • 論文タイトル : Phagocytic Glial Cells in Brain Homeostasis.
    著者:Kono R, Ikegaya Y, Koyama R.
    雑誌情報:Cells. 2021 Jun; 10(6): 1348.

  • 論文タイトル : Oligodendrocytic Na+-K+-Cl- co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain.
    著者:Yamazaki Y, Abe Y, Fujii S, Tanaka KF.
    雑誌情報:Nat Commun. 2021 Aug 26;12(1):5146. doi: 10.1038/s41467-021-25488-5.

  • 論文タイトル : Glial amplification of synaptic signals.
    著者:Beppu K, Kubo N, Matsui K.
    雑誌情報:Journal of Physiology, 599: 2085-2102.
    DOI: https://doi.org/10.1113/JP280857

  • 論文タイトル : Reactive astrocyte nomenclature, definitions, and future directions.
    著者 : Escartin C, Galea E, Lakatos A, O’Callaghan JP, Petzold GC, Serrano-Pozo A, Steinhäuser C, Volterra A, Carmignoto G, Agarwal A, Allen NJ, Araque A, Barbeito L, Barzilai A, Bergles DE, Bonvento G, Butt AM, Chen WT, Cohen-Salmon M, Cunningham C, Deneen B, De Strooper B, Díaz-Castro B, Farina C, Freeman M, Gallo V, Goldman JE, Goldman SA, Götz M, Gutiérrez A, Haydon PG, Heiland DH, Hol EM, Holt MG, Iino M, Kastanenka KV, Kettenmann H, Khakh BS, Koizumi S, Lee CJ, Liddelow SA, MacVicar BA, Magistretti P, Messing A, Mishra A, Molofsky AV, Murai KK, Norris CM, Okada S, Oliet SHR, Oliveira JF, Panatier A, Parpura V, Pekna M, Pekny M, Pellerin L, Perea G, Pérez-Nievas BG, Pfrieger FW, Poskanzer KE, Quintana FJ, Ransohoff RM, Riquelme-Perez M, Robel S, Rose CR, Rothstein JD, Rouach N, Rowitch DH, Semyanov A, Sirko S, Sontheimer H, Swanson RA, Vitorica J, Wanner IB, Wood LB, Wu J, Zheng B, Zimmer ER, Zorec R, Sofroniew MV, Verkhratsky A.
    雑誌情報 : Nat Neurosci. 2021 Mar;24(3):312-325. doi: 10.1038/s41593-020-00783-4. Epub 2021 Feb 15.PMID: 33589835

  • 論文タイトル : Pain induces stable, active microcircuits in the somatosensory cortex that provide a therapeutic target
    著者 : Okada T, Kato D, Nomura Y, Obata N, Quan X, Morinaga A, Yano H, Guo Z, Aoyama Y, Tachibana Y, Moorhouse AJ, Matoba O, Takiguchi T, Mizobuchi S, Wake H.
    雑誌情報 : Sci Adv. 2021 Mar 19;7(12):eabd8261. doi: 10.1126/sciadv.abd8261. Print 2021 Mar.PMID: 33741588

  • 論文タイトル : Spinal astrocytes in superficial laminae gate brainstem descending control of mechanosensory hypersensitivity.
    著者 : Kohro Y, Matsuda T, Yoshihara K, Kohno K, Koga K, Katsuragi R, Oka T, Tashima R, Muneta S, Yamane T, Okada S, Momokino K, Furusho A, Hamase K, Oti T, Sakamoto H, Hayashida K, Kobayashi R, Horii T, Hatada I, Tozaki-Saitoh H, Mikoshiba K, Taylor V, Inoue K, Tsuda M.
    雑誌情報 : Nat Neurosci. 23(11): 1376-1387 (2020). DOI: 10.1038/s41593-020-00713-4

  • 論文タイトル : Microglia regulate synaptic development and plasticity.
    著者 : Andoh M, Koyama R.
    雑誌情報 : Dev Neurobiol. 2021 Feb 14. doi: 10.1002/dneu.22814.


  • 論文タイトル : Astrocytic cAMP modulates memory via synaptic plasticity.
    著者 : Zhou Z, Okamoto K, Onodera J, Hiragi T, Andoh M, Ikawa M, Tanaka KF, Ikegaya Y, Koyama R.
    雑誌情報 : Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2016584118. doi: 10.1073/pnas.2016584118. PMID: 33452135

  • 論文タイトル : Exacerbation of epilepsy by astrocyte alkalization and gap junction uncoupling.
    著者 : Onodera M, Meyer J, Furukawa K, Hiraoka Y, Aida T, Tanaka K, Tanaka KF, Rose CR, Matsui K*
    雑誌情報 : Journal of Neuroscience, 41: 2106-2118.
    DOI: https://doi.org/10.1523/JNEUROSCI.2365-20.2020