研究成果

  • 論文タイトル :Adenosine A2B Receptor down-regulates Metabotropic Glutamate Receptor 5 in astrocytes during postnatal development.
    著者 Tanaka M, Shigetomi E, Parajuli B, Nagatomo H, Shinozaki Y, Hirayama Y, Saito K, Kubota Y, Danjo Y, Lee JH, Kim SK, Nabekura J, Koizumi S.
    雑誌情報 :GLIA, 2021 Nov: 69(11):2546-2558. doi: 10.1002/glia.24006.

  • 論文タイトル :Transnasal transplantation of human induced pluripotent stem cell-derived microglia to the brain of immunocompetent mice.
    著者 Parajuli B, Saito H, Shinozaki Y, Shigetomi E, Miwa H, Yoneda S, Omachi S, Asaki T, Takahashi K, Fujita M, Nakashima, K and Koizumi S.
    雑誌情報 :GLIA, 2021 Oct; 69(10):2332-2348. doi: 10.1002/glia.23985.

  • 論文タイトル : Mechanisms underlying sensitization of P2X7 receptors in astrocytes for induction of ischemic tolerance.
    著者 Hirayama Y, Anzai N, Koizumi S.
    雑誌情報 :GLIA, 2021 Sep; 69(9):2100-2110. DOI: 10.1002/glia.23998.

  • 論文タイトル : Loss of P2Y1 receptor triggers glaucoma-like pathology.
    著者 Hamada K, Shinozaki Y, Namekata K, Matsumoto M, Ohno N, Segawa T, Kashiwagi K, Harada T and Koizumi S.
    雑誌情報 :Br J Pharmacol, 2021 Jul 26; in press. doi: 10.1111/bph.15637.

  • 論文タイトル : Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus.
    著者 Sano F, Shigetomi E, Shinozaki Y, Tsuzukiyama H, Saito K, Mikoshiba K, Horiuchi H, Cheung DL, Nabekura J, Sugita K, Aihara M, *Koizumi S.
    雑誌情報 :JCI Insight, 2021 May10; 6(9): e135391. doi: 10.1172/jci.insight.135391.

  • 論文タイトル : The behavior and functions of embryonic microglia.
    著者 Hattori Y.
    雑誌情報 :Anat Sci Int. 2021 Sep 19; Online ahead of print. doi: 10/1007/s12565-021-00631-w

  • 論文タイトル : Specific and behaviorally consequential astrocyte Gq-GPCR signaling attenuation in vivo with ibARK.
    著者 Nagai J, Bellafard A, Qu Z, Yu X, Ollivier M, Gangwani MR, Diaz-Castro B, Coppola G, Schumacher SM, Golshani P, Gradinaru V, Khakh BS.
    雑誌情報 :Neuron. 2021 Jun 109(14):2256-2274. doi: 10.1016/j.neuron.2021.05.023

  • 論文タイトル : Optical manipulation of local cerebral blood flow in the deep brain of freely moving mice.
    著者 : Abe Y, Kwon S, Oishi M, Unekawa M, Takata N, Seki F, Koyama R, Abe M, Sakimura K, Masamoto K, Tomita Y, Okano H, Mushiake H, Tanaka KF.
    雑誌情報 : Cell Rep. 2021 Jul 27;36(4):109427. doi: 10.1016/j.celrep.2021.109427

  • 論文タイトル : Phagocytic Glial Cells in Brain Homeostasis.
    著者 : Kono R, Ikegaya Y, Koyama R.
    雑誌情報 : Cells. 2021 Jun; 10(6): 1348.

  • 論文タイトル : Oligodendrocytic Na+-K+-Cl- co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain.
    著者 Yamazaki Y, Abe Y, Fujii S, Tanaka KF.
    雑誌情報 : Nat Commun. 2021 Aug 26;12(1):5146. doi: 10.1038/s41467-021-25488-5.

  • 論文タイトル : Glial amplification of synaptic signals.
    著者 : Beppu K, Kubo N, Matsui K.
    雑誌情報 : Journal of Physiology, 599: 2085-2102.
    DOI: https://doi.org/10.1113/JP280857

  • 論文タイトル : Reactive astrocyte nomenclature, definitions, and future directions.
    著者 : Escartin C, Galea E, Lakatos A, O’Callaghan JP, Petzold GC, Serrano-Pozo A, Steinhäuser C, Volterra A, Carmignoto G, Agarwal A, Allen NJ, Araque A, Barbeito L, Barzilai A, Bergles DE, Bonvento G, Butt AM, Chen WT, Cohen-Salmon M, Cunningham C, Deneen B, De Strooper B, Díaz-Castro B, Farina C, Freeman M, Gallo V, Goldman JE, Goldman SA, Götz M, Gutiérrez A, Haydon PG, Heiland DH, Hol EM, Holt MG, Iino M, Kastanenka KV, Kettenmann H, Khakh BS, Koizumi S, Lee CJ, Liddelow SA, MacVicar BA, Magistretti P, Messing A, Mishra A, Molofsky AV, Murai KK, Norris CM, Okada S, Oliet SHR, Oliveira JF, Panatier A, Parpura V, Pekna M, Pekny M, Pellerin L, Perea G, Pérez-Nievas BG, Pfrieger FW, Poskanzer KE, Quintana FJ, Ransohoff RM, Riquelme-Perez M, Robel S, Rose CR, Rothstein JD, Rouach N, Rowitch DH, Semyanov A, Sirko S, Sontheimer H, Swanson RA, Vitorica J, Wanner IB, Wood LB, Wu J, Zheng B, Zimmer ER, Zorec R, Sofroniew MV, Verkhratsky A.
    雑誌情報 : Nat Neurosci. 2021 Mar;24(3):312-325. doi: 10.1038/s41593-020-00783-4. Epub 2021 Feb 15.PMID: 33589835

  • 論文タイトル : Pain induces stable, active microcircuits in the somatosensory cortex that provide a therapeutic target
    著者 : Okada T, Kato D, Nomura Y, Obata N, Quan X, Morinaga A, Yano H, Guo Z, Aoyama Y, Tachibana Y, Moorhouse AJ, Matoba O, Takiguchi T, Mizobuchi S, Wake H.
    雑誌情報 : Sci Adv. 2021 Mar 19;7(12):eabd8261. doi: 10.1126/sciadv.abd8261. Print 2021 Mar.PMID: 33741588

  • 論文タイトル : Spinal astrocytes in superficial laminae gate brainstem descending control of mechanosensory hypersensitivity.
    著者 : Kohro Y, Matsuda T, Yoshihara K, Kohno K, Koga K, Katsuragi R, Oka T, Tashima R, Muneta S, Yamane T, Okada S, Momokino K, Furusho A, Hamase K, Oti T, Sakamoto H, Hayashida K, Kobayashi R, Horii T, Hatada I, Tozaki-Saitoh H, Mikoshiba K, Taylor V, Inoue K, Tsuda M.
    雑誌情報 : Nat Neurosci. 23(11): 1376-1387 (2020). DOI: 10.1038/s41593-020-00713-4

  • 論文タイトル : Microglia regulate synaptic development and plasticity.
    著者 : Andoh M, Koyama R.
    雑誌情報 : Dev Neurobiol. 2021 Feb 14. doi: 10.1002/dneu.22814.


  • 論文タイトル : Astrocytic cAMP modulates memory via synaptic plasticity.
    著者 : Zhou Z, Okamoto K, Onodera J, Hiragi T, Andoh M, Ikawa M, Tanaka KF, Ikegaya Y, Koyama R.
    雑誌情報 : Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2016584118. doi: 10.1073/pnas.2016584118. PMID: 33452135

  • 論文タイトル : Exacerbation of epilepsy by astrocyte alkalization and gap junction uncoupling.
    著者 : Onodera M, Meyer J, Furukawa K, Hiraoka Y, Aida T, Tanaka K, Tanaka KF, Rose CR, Matsui K*
    雑誌情報 : Journal of Neuroscience, 41: 2106-2118.
    DOI: https://doi.org/10.1523/JNEUROSCI.2365-20.2020